Haplotype Analyses of Haemoglobin C and Haemoglobin S and the Dynamics of the Evolutionary Response to Malaria in Kassena-Nankana District of Ghana

BACKGROUND: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investiga...

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Main Authors: Ghansah, Anita, Rockett, Kirk A., Clark, Taane G., Wilson, Michael D., Koram, Kwadwo A., Oduro, Abraham R., Amenga-Etego, Lucas, Anyorigiya, Thomas, Hodgson, Abraham, Milligan, Paul, Rogers, William O., Kwiatkowski, Dominic P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323552/
https://ncbi.nlm.nih.gov/pubmed/22506028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034565
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