Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

OBJECTIVES: To examine the effects of combination therapy with metformin and paclitaxel in endometrial cancer cell lines. METHODS: ECC-1 and Ishikawa endometrial cancer cell lines were used. Cell proliferation was assessed after exposure to paclitaxel and metformin. Cell cycle progression was assess...

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Main Authors: Hanna, Rabbie K., Zhou, Chunxiao, Malloy, Kimberly M., Gehrig, Paola A, Bae-Jump, Victoria L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322276/
https://ncbi.nlm.nih.gov/pubmed/22252099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2012.01.009
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