Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

Expansion of human stem cells before cell therapy is typically performed at 20% O(2). Growth in these pro-oxidative conditions can lead to oxidative stress and genetic instability. Here, we demonstrate that culture of human mesenchymal stem cells at lower, physiological O(2) concentrations significa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Estrada, J C, Albo, C, Benguría, A, Dopazo, A, López-Romero, P, Carrera-Quintanar, L, Roche, E, Clemente, E P, Enríquez, J A, Bernad, A, Samper, E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321628/
https://ncbi.nlm.nih.gov/pubmed/22139129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.172
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