Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown, dependent on context, to be both injurious and protective. Human pluripotent stem cells offer a powerful new system to improve our understanding...

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Main Authors: Gupta, K, Patani, R, Baxter, P, Serio, A, Story, D, Tsujita, T, Hayes, J D, Pedersen, R A, Hardingham, G E, Chandran, S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321621/
https://ncbi.nlm.nih.gov/pubmed/22095276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.154
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