Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two human cell lines, we performed an siRNA-based functional high-content microscopy screen fo...

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Detalhes bibliográficos
Main Authors: Moudry, P, Lukas, C, Macurek, L, Neumann, B, Heriche, J-K, Pepperkok, R, Ellenberg, J, Hodny, Z, Lukas, J, Bartek, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321618/
https://ncbi.nlm.nih.gov/pubmed/22075984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.150
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