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HIV Develops Indirect Cross-resistance to Combinatorial RNAi Targeting Two Distinct and Spatially Distant Sites

Resistance to existing HIV therapies is an increasing problem, and alternative treatments are urgently needed. RNA interference (RNAi), an innate mechanism for sequence-specific gene silencing, can be harnessed therapeutically to treat viral infections, yet viral resistance can still emerge. Here, w...

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Bibliografiske detaljer
Main Authors: Shah, Priya S, Pham, Nhung P, Schaffer, David V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321590/
https://ncbi.nlm.nih.gov/pubmed/22294151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.3
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