Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors

Inefficient vascularization hinders the optimal transport of cell nutrients, oxygen, and drugs to cancer cells in solid tumors. Gradients of these substances maintain a heterogeneous cell-scale microenvironment through which drugs and their carriers must travel, significantly limiting optimal drug e...

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Autori principali: van de Ven, Anne L., Wu, Min, Lowengrub, John, McDougall, Steven R., Chaplain, Mark A. J., Cristini, Vittorio, Ferrari, Mauro, Frieboes, Hermann B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Copyright 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. 2012
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Contributed Articles on Physics of Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321519/
https://ncbi.nlm.nih.gov/pubmed/22489278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3699060
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