G Protein-coupled Receptor Kinase-5 Attenuates Atherosclerosis by Regulating Receptor Tyrosine Kinases and 7-transmembrane Receptors

OBJECTIVE: G protein-coupled receptor kinase-5 (GRK5) is a widely expressed Ser/Thr kinase that regulates several atherogenic receptors, and may activate or inhibit NFκB. This study sought to determine whether and by what mechanisms GRK5 affects atherosclerosis. METHODS AND RESULTS: Grk5(−/−)/Apoe(−...

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Autores principales: Wu, Jiao-Hui, Zhang, Lisheng, Fanaroff, Alexander C., Cai, Xinjiang, Sharma, Krishn C., Brian, Leigh, Exum, Sabrina T., Shenoy, Sudha K., Peppel, Karsten, Freedman, Neil J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321515/
https://ncbi.nlm.nih.gov/pubmed/22095977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.239608
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