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Axl is essential for VEGF-A-dependent activation of PI3K/Akt
Herein, we report that vascular endothelial growth factor A (VEGF-A) engages the PI3K/Akt pathway by a previously unknown mechanism that involves three tyrosine kinases. Upon VEGF-A-dependent activation of VEGF receptor-2 (VEGFR-2), and subsequent TSAd-mediated activation of Src family kinases (SFKs...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321201/ https://ncbi.nlm.nih.gov/pubmed/22327215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.21 |
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