PML regulates PER2 nuclear localization and circadian function

Studies have suggested that the clock regulator PER2 is a tumour suppressor. A cancer network involving PER2 raises the possibility that some tumour suppressors are directly involved in the mammalian clock. Here, we show that the tumour suppressor promyelocytic leukaemia (PML) protein is a circadian...

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Hauptverfasser: Miki, Takao, Xu, Zhixiang, Chen-Goodspeed, Misty, Liu, Mingguang, Van Oort-Jansen, Anita, Rea, Michael A, Zhao, Zhaoyang, Lee, Cheng Chi, Chang, Kun-Sang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321181/
https://ncbi.nlm.nih.gov/pubmed/22274616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.1
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