Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms (PanINs)—the most common precursors of pancreatic ductal adenocarcinoma. We show that >99% of the earliest stage, lowest-grade, PanIN-1 lesions contain mutations in KRAS, p16/CDKN2A,...

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Detalhes bibliográficos
Main Authors: Kanda, Mitsuro, Matthaei, Hanno, Wu, Jian, Hong, Seung-Mo, Yu, Jun, Borges, Michael, Hruban, Ralph H., Maitra, Anirban, Kinzler, Kenneth, Vogelstein, Bert, Goggins, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321090/
https://ncbi.nlm.nih.gov/pubmed/22226782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.12.042
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