Outer Membrane Protein A (OmpA) of Shigella flexneri 2a Links Innate and Adaptive Immunity in a TLR2-dependent Manner and Involvement of IL-12 and Nitric Oxide

We determine that OmpA of Shigella flexneri 2a is recognized by TLR2 and consequently mediates the release of proinflammatory cytokines and activates NF-κB in HEK 293 cells transfected with TLR2. We also observe that in RAW macrophages TLR2 is essential to instigate the early immune response to OmpA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pore, Debasis, Mahata, Nibedita, Chakrabarti, Manoj K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321007/
https://ncbi.nlm.nih.gov/pubmed/22343631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335554
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