A Bridging [4Fe-4S] Cluster and Nucleotide Binding Are Essential for Function of the Cfd1-Nbp35 Complex as a Scaffold in Iron-Sulfur Protein Maturation

The essential P-loop NTPases Cfd1 and Nbp35 of the cytosolic iron-sulfur (Fe-S) protein assembly machinery perform a scaffold function for Fe-S cluster synthesis. Both proteins contain a nucleotide binding motif of unknown function and a C-terminal motif with four conserved cysteine residues. The la...

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Autores principales: Netz, Daili J. A., Pierik, Antonio J., Stümpfig, Martin, Bill, Eckhard, Sharma, Anil K., Pallesen, Leif J., Walden, William E., Lill, Roland
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320986/
https://ncbi.nlm.nih.gov/pubmed/22362766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328914
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