Familial Focal Segmental Glomerulosclerosis (FSGS)-linked α-Actinin 4 (ACTN4) Protein Mutants Lose Ability to Activate Transcription by Nuclear Hormone Receptors

Mutations in α-actinin 4 (ACTN4) are linked to familial forms of focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria due to podocyte injury. The mechanisms underlying ACTN4 mutant-associated FSGS are not completely understood. Although α-actinins are better known...

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Hlavní autoři: Khurana, Simran, Chakraborty, Sharmistha, Lam, Minh, Liu, Yu, Su, Yu-Ting, Zhao, Xuan, Saleem, Moin A., Mathieson, Peter W., Bruggeman, Leslie A., Kao, Hung-Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320949/
https://ncbi.nlm.nih.gov/pubmed/22351778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345421
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