A human 3′ miR-499 mutation alters cardiac mRNA targeting and function

RATIONALE: MyomiRs miR-499, miR-208a and miR-208b direct cardiac myosin gene expression. Sequence complementarity between miRs and their mRNA targets determines miR effects, but the functional consequences of human myomiR sequence variants are unknown. OBJECTIVE: To identify and investigate mutation...

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Bibliographic Details
Main Authors:	Dorn, Gerald W, Matkovich, Scot J, Eschenbacher, William H, Zhang, Yan
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3320730/ https://ncbi.nlm.nih.gov/pubmed/22374132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.260752
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A human 3′ miR-499 mutation alters cardiac mRNA targeting and function

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