Rational Incorporation of Selenium into Temozolomide Elicits Superior Antitumor Activity Associated with Both Apoptotic and Autophagic Cell Death

BACKGROUND: The DNA alkylating agent temozolomide (TMZ) is widely used in the treatment of human malignancies such as glioma and melanoma. On the basis of previous structure-activity studies, we recently synthesized a new TMZ selenium analog by rationally introducing an N-ethylselenocyanate extensio...

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Bibliografiske detaljer
Main Authors: Cheng, Yan, Sk, Ugir Hossain, Zhang, Yi, Ren, Xingcong, Zhang, Li, Huber-Keener, Kathryn J., Sun, Yuan-Wan, Liao, Jason, Amin, Shantu, Sharma, Arun K., Yang, Jin-Ming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320619/
https://ncbi.nlm.nih.gov/pubmed/22496897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035104
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