Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1(−/−) Mice

The histone deacetylase sirtuin 1 (SIRT1) inhibits adipocyte differentiation and suppresses inflammation by targeting the transcription factors peroxisome proliferator-activated receptor γ and nuclear factor κB. Although this suggests that adiposity and inflammation should be enhanced when SIRT1 act...

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Bibliographic Details
Main Authors: Xu, Fen, Burk, David, Gao, Zhanguo, Yin, Jun, Zhang, Xia, Weng, Jianping, Ye, Jianping
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Energy Balance-Obesity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320251/
https://ncbi.nlm.nih.gov/pubmed/22315447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1667
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