Ultrastructural and Immunohistochemical Studies on Uptake and Distribution of FITC-Conjugated PLGA Nanoparticles Administered Intratracheally in Rats

Polylactide-glycolide (PLGA) nanoparticles have been developed as pulmonary drug delivery carriers. To investigate their behavior, small- (d50 = 74 nm) and large-sized (d50 = 250 nm) FITC-conjugated PLGA nanoparticles were intratracheally administered to rats and were traced for 5, 30 and 60 minutes...

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Main Authors: Hara, Kaori, Tsujimoto, Hiroyuki, Huang, C. C., Kawashima, Yoshiaki, Ando, Rie, Kusuoka, Osamu, Tamura, Kazutoshi, Tsutsumi, Masahiro
Format: Artigo
Jezik:Inglês
Izdano: Japanese Society of Toxicologic Pathology 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320153/
https://ncbi.nlm.nih.gov/pubmed/22481855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.25.19
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