Functional and Structural Analysis of the Internal Ribosome Entry Site Present in the mRNA of Natural Variants of the HIV-1

The 5′untranslated regions (UTR) of the full length mRNA of the HIV-1 proviral clones pNL4.3 and pLAI, harbor an internal ribosomal entry site (IRES). In this study we extend this finding by demonstrating that the mRNA 5′UTRs of natural variants of HIV-1 also exhibit IRES-activity. Cap-independent t...

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Main Authors: Vallejos, Maricarmen, Carvajal, Felipe, Pino, Karla, Navarrete, Camilo, Ferres, Marcela, Huidobro-Toro, Juan Pablo, Sargueil, Bruno, López-Lastra, Marcelo
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319624/
https://ncbi.nlm.nih.gov/pubmed/22496887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035031
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