Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination

BACKGROUND: The Step trial raised the possibility that uncircumcised men with pre-existing Ad5 neutralizing antibodies carried an increased risk of HIV infection after vaccination. Thus, understanding Ad seropositivity in humans is important to the development of an AIDS vaccine. Here, we analyze th...

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Main Authors: Cheng, Cheng, Wang, LingShu, Gall, Jason G. D., Nason, Martha, Schwartz, Richard M., McElrath, M. Juliana, DeRosa, Steven C., Hural, John, Corey, Lawrence, Buchbinder, Susan P., Nabel, Gary J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319553/
https://ncbi.nlm.nih.gov/pubmed/22496775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033969
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