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Mechanism of NO binding to soluble guanylyl cyclase: implication for the second NO binding to the heme proximal site
Soluble guanylyl cyclase (sGC), the key enzyme for the formation of second messenger cyclic GMP (cGMP), is an authentic sensor for nitric oxide (NO). Binding of NO to sGC leads to strong activation of the enzyme activity. Multiple molecules and steps of NO binding to sGC have been implicated, but th...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319481/ https://ncbi.nlm.nih.gov/pubmed/22401134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300105s |
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