Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV.

An improved procedure for the preparation of 3-deaza-2'-deoxyadenosine (d3CA) is described which is suitable for the synthesis of gram quantities of this analogue. Using phosphoramidite chemistry d3CA has been incorporated into the Eco RV restiction endonuclease recognition sequence (underlined) pre...

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Publicado en:	Nucleic Acids Res
Autores principales:	Cosstick, R, Li, X, Tuli, D K, Williams, D M, Connolly, B A, Newman, P C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1990
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC331941/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2395641/
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