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BETAINE PREVENTS MALLORY-DENK BODY FORMATION IN DRUG-PRIMED MICE BY EPIGENETIC MECHANISMS

Previous studies showed that S-Adenosylmethionine (SAMe) prevented MDB formation and the hypomethylation of histones induced by DDC feeding. These results suggest that formation of MDBs is an epigenetic phenomenon. To further test this theory, drug-primed mice were fed the methyl donor, betaine, tog...

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Detalhes bibliográficos
Main Authors: Oliva, Joan, Bardag-Gorce, Fawzia, Li, Jun, French, Barbara A, Nguyen, Sheila K., Lu, Shelly C., French, Samuel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319154/
https://ncbi.nlm.nih.gov/pubmed/19073172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2008.11.002
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