Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Revealed by Proteomic and Transcriptomic Analyses of the Striata in Two Mouse Models of Parkinson’s Disease

The molecular mechanisms underlying the changes in the nigrostriatal pathway in Parkinson’s disease (PD) are not completely understood. Here, we use mass spectrometry and microarrays to study the proteomic and transcriptomic changes in the striatum of two mouse models of PD, induced by the distinct...

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Bibliografiske detaljer
Main Authors: Chin, Mark H., Qian, Wei-Jun, Wang, Haixing, Petyuk, Vladislav A., Bloom, Joshua S., Sforza, Daniel M., Laćan, Goran, Liu, Dahai, Khan, Arshad H., Cantor, Rita M., Bigelow, Diana J., Melega, William P., Camp, David G., Smith, Richard D., Smith, Desmond J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319057/
https://ncbi.nlm.nih.gov/pubmed/18173235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr070546l
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