Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis

Mycobacterium tuberculosis possesses unique cell-surface lipids that have been implicated in virulence. One of the most abundant is sulfolipid-1 (SL-1), a tetraacyl-sulfotrehalose glycolipid. Although the early steps in SL-1 biosynthesis are known, the machinery underlying the final acylation reacti...

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Détails bibliographiques
Auteurs principaux: Seeliger, Jessica C., Holsclaw, Cynthia M., Schelle, Michael W., Botyanszki, Zsofia, Gilmore, Sarah A., Tully, Sarah E., Niederweis, Michael, Cravatt, Benjamin F., Leary, Julie A., Bertozzi, Carolyn R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318749/
https://ncbi.nlm.nih.gov/pubmed/22194604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315473
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