Substrate Specificity of the Two Mitochondrial Ornithine Carriers Can Be Swapped by Single Mutation in Substrate Binding Site

Mitochondrial carriers are a large family of proteins that transport specific metabolites across the inner mitochondrial membrane. Sequence and structure analysis has indicated that these transporters have substrate binding sites in a similar location of the central cavity consisting of three major...

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Bibliografiska uppgifter
Huvudupphovsmän: Monné, Magnus, Miniero, Daniela Valeria, Daddabbo, Lucia, Robinson, Alan J., Kunji, Edmund R. S., Palmieri, Ferdinando
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318746/
https://ncbi.nlm.nih.gov/pubmed/22262851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324855
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