Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways

Perturbations in the adipocytokine profile, especially higher levels of leptin, are a major cause of breast tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether leptin is involved in epithelial-mesenchymal transition...

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Bibliografski detalji
Glavni autori: Yan, Dan, Avtanski, Dimiter, Saxena, Neeraj K., Sharma, Dipali
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Signal Transduction
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318705/
https://ncbi.nlm.nih.gov/pubmed/22270359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322800
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