Latency Type-Dependent Modulation of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Expression by Type I Interferons in B Cells

We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not p...

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Autores principales: Salamon, Daniel, Adori, Monika, Ujvari, Dorina, Wu, Liang, Kis, Lorand L., Madapura, Harsha S., Nagy, Noemi, Klein, George, Klein, Eva
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318621/
https://ncbi.nlm.nih.gov/pubmed/22345482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06829-11
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