High Proportion of Fluoroquinolone-Resistant Mycobacterium tuberculosis Isolates with Novel Gyrase Polymorphisms and a gyrA Region Associated with Fluoroquinolone Susceptibility

Fluoroquinolone resistance in Mycobacterium tuberculosis can be conferred by mutations in gyrA or gyrB. The prevalence of resistance mutations outside the quinolone resistance-determining region (QRDR) of gyrA or gyrB is unclear, since such regions are rarely sequenced. M. tuberculosis isolates from...

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Autori principali: Devasia, Rose, Blackman, Amondrea, Eden, Svetlana, Li, Haijing, Maruri, Fernanda, Shintani, Ayumi, Alexander, Charles, Kaiga, Anne, Stratton, Charles W., Warkentin, Jon, Tang, Yi-Wei, Sterling, Timothy R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Mycobacteriology and Aerobic Actinomycetes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318526/
https://ncbi.nlm.nih.gov/pubmed/22189117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.05286-11
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