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NDM-4 Metallo-β-Lactamase with Increased Carbapenemase Activity from Escherichia coli
A clinical Escherichia coli isolate resistant to all β-lactams, including carbapenems, expressed a novel metallo-β-lactamase (MBL), NDM-4, differing from NDM-1 by a single amino acid substitution (Met154Leu). NDM-4 possessed increased hydrolytic activity toward carbapenems and several cephalosporins...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318389/ https://ncbi.nlm.nih.gov/pubmed/22252797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05961-11 |
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