Degradation of Nuclease-Stabilized RNA Oligonucleotides in Mycoplasma-Contaminated Cell Culture Media

Artificial RNA reagents such as small interfering RNAs (siRNAs) and aptamers often must be chemically modified for optimal effectiveness in environments that include ribonucleases. Mycoplasmas are common bacterial contaminants of mammalian cell cultures that are known to produce ribonucleases. Here...

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Main Authors: Hernandez, Frank J., Stockdale, Katie R., Huang, Lingyan, Horswill, Alexander R., Behlke, Mark A., McNamara, James O.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318257/
https://ncbi.nlm.nih.gov/pubmed/22229275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2011.0316
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