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Influence of Hydrophobic Mismatch on Structures and Dynamics of Gramicidin A and Lipid Bilayers

Gramicidin A (gA) is a 15-amino-acid antibiotic peptide with an alternating L-D sequence, which forms (dimeric) bilayer-spanning, monovalent cation channels in biological membranes and synthetic bilayers. We performed molecular dynamics simulations of gA dimers and monomers in all-atom, explicit dil...

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Detalhes bibliográficos
Main Authors: Kim, Taehoon, Lee, Kyu Il, Morris, Phillip, Pastor, Richard W., Andersen, Olaf S., Im, Wonpil
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318127/
https://ncbi.nlm.nih.gov/pubmed/22500755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.014
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