Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration

The molecular mechanism of β-cell regeneration remains poorly understood. Cyclin D2/CDK4 expresses in normal β cells and maintains adult β-cell growth. We hypothesized that gene therapy with cyclin D2/CDK4/GLP-1 plasmids targeted to the pancreas of STZ-treated rats by ultrasound-targeted microbubble...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Shuyuan, Shimoda, Masyuki, Chen, Jiaxi, Matsumodo, Shinichi, Grayburn, Paul A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2012
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318104/
https://ncbi.nlm.nih.gov/pubmed/22373529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.4.19120
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