Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription

CREB mediates the transcriptional effects of glucose and incretin hormones in insulin-target cells and insulin-producing β-cells. Although the inhibition of CREB activity is known to decrease the β-cell mass, it is still unknown what factors inversely alter the CREB signaling pathway in β-cells. Her...

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Bibliographische Detailangaben
Hauptverfasser: Cho, In-Su, Jung, Miyoung, Kwon, Ki-Sun, Moon, Eunpyo, Cho, Jang-Hyeon, Yoon, Kun-Ho, Kim, Ji-Won, Lee, Young-Don, Kim, Sung-Soo, Suh-Kim, Haeyoung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318007/
https://ncbi.nlm.nih.gov/pubmed/22509362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034860
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