Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

BRCA1 is a breast and ovarian cancer-specific tumor suppressor that seems to be involved in transcription and DNA repair. Here we report that BRCA1 exhibits a bona fide ubiquitin (Ub) protein ligase (E3) activity, and that cancer-predisposing mutations within the BRCA1 RING domain abolish its Ub lig...

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Main Authors: Ruffner, Heinz, Joazeiro, Claudio A. P., Hemmati, Dan, Hunter, Tony, Verma, Inder M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33176/
https://ncbi.nlm.nih.gov/pubmed/11320250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081068398
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