Primary cilia mediate mechanotransduction through control of ATP-induced Ca(2+) signaling in compressed chondrocytes

We investigated the role of the chondrocyte primary cilium in mechanotransduction events related to cartilage extracellular matrix synthesis. We generated conditionally immortalized wild-type (WT) and IFT88(orpk) (ORPK) mutant chondrocytes that lack primary cilia and assessed intracellular Ca(2+) si...

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Detalhes bibliográficos
Main Authors: Wann, Angus K. T., Zuo, Ning, Haycraft, Courtney J., Jensen, Cynthia G., Poole, C. Anthony, McGlashan, Susan R., Knight, Martin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316893/
https://ncbi.nlm.nih.gov/pubmed/22223751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-193649
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