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Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice
The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, an...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Springer-Verlag
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3316750/ https://ncbi.nlm.nih.gov/pubmed/22328270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-012-0282-x |
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