Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice

To study mechanisms of T cell-mediated rejection of B cell lymphomas, we developed a murine lymphoma model wherein three potential rejection antigens, human c-MYC, chicken ovalbumin (OVA), and GFP are expressed. After transfer into wild-type mice 60–70% of systemically growing lymphomas expressing a...

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Detalhes bibliográficos
Main Authors: Gerbitz, Armin, Sukumar, Madhusudhanan, Helm, Florian, Wilke, Andrea, Friese, Christian, Fahrenwaldt, Cornelia, Lehmann, Frank M., Loddenkemper, Christoph, Kammertoens, Thomas, Mautner, Josef, Schmitt, Clemens A., Blankenstein, Thomas, Bornkamm, Georg W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316708/
https://ncbi.nlm.nih.gov/pubmed/22479645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034552
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