CFTR: A molecular model defines the architecture of the anion conduction path and locates a “bottleneck” in the pore

We developed molecular models for the CFTR chloride channel based on the prokaryotic ABC transporter, Sav1866. Here we analyze predicted pore geometry and side-chain orientations for TMs 3, 6, 9 and 12; with particular attention to the location of the rate-limiting barrier for anion conduction. Side...

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Hlavní autoři: Norimatsu, Yohei, Ivetac, Anthony, Alexander, Christopher, Kirkham, John, O’Donnell, Nicolette, Dawson, David C., Sansom, Mark S.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316148/
https://ncbi.nlm.nih.gov/pubmed/22352759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201888a
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