NAHA, a Novel Hydroxamic Acid-Derivative, Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo

BACKGROUND: We have recently synthesized novel N-alkylated amino acid-derived hydroxamate, 2-[Benzyl-(2-nitro-benzenesulfonyl)-amino]-N-hydroxy-3-methyl-N-propyl-butyramide (NAHA). Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro...

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Bibliographic Details
Main Authors: Jiang, Jiahua, Thyagarajan-Sahu, Anita, Krchňák, Viktor, Jedinak, Andrej, Sandusky, George E., Sliva, Daniel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315582/
https://ncbi.nlm.nih.gov/pubmed/22479587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034283
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