Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era

INTRODUCTION: Pre-temozolomide studies demonstrated that loss of the tumor suppressor gene PTEN held independent prognostic significance in GBM patients. We investigated whether loss of PTEN predicted shorter survival in the temozolomide era. The role of PTEN in the PI3K/Akt pathway is also reviewed...

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Detalhes bibliográficos
Main Authors: Carico, Christine, Nuño, Miriam, Mukherjee, Debraj, Elramsisy, Adam, Dantis, Jocelynn, Hu, Jethro, Rudnick, Jeremy, Yu, John S., Black, Keith L., Bannykh, Serguei I., Patil, Chirag G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315579/
https://ncbi.nlm.nih.gov/pubmed/22479427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033684
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