Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

Increased de novo fatty acid (FA) synthesis is one hallmark of tumor cells, including prostate cancer (PC). We present here our most recent results showing that lipids composition in human prostate cancer (PC) is characterized by an increased ratio of monounsaturated FA (MUFA) to saturated FA (SFA),...

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Detalhes bibliográficos
Main Authors: Fritz, Vanessa, Benfodda, Zohra, Rodier, Geneviève, Henriquet, Corinne, Iborra, François, Avancès, Christophe, Allory, Yves, De La Taille, Alexandre, Culine, Stéphane, Blancou, Hubert, Cristol, Jean Paul, Michel, Françoise, Sardet, Claude, Fajas, Lluis
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research, Inc 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315476/
https://ncbi.nlm.nih.gov/pubmed/20530718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1064
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