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Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

The efficiency of translation termination depends on the nature of the stop codon and the surrounding nucleotides. Some molecules, such as aminoglycoside antibiotics (gentamicin), decrease termination efficiency and are currently being evaluated for diseases caused by premature termination codons. H...

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מידע ביבליוגרפי
Main Authors: Floquet, Célia, Hatin, Isabelle, Rousset, Jean-Pierre, Bidou, Laure
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315467/
https://ncbi.nlm.nih.gov/pubmed/22479203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002608
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