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Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

The efficiency of translation termination depends on the nature of the stop codon and the surrounding nucleotides. Some molecules, such as aminoglycoside antibiotics (gentamicin), decrease termination efficiency and are currently being evaluated for diseases caused by premature termination codons. H...

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書誌詳細
主要な著者: Floquet, Célia, Hatin, Isabelle, Rousset, Jean-Pierre, Bidou, Laure
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315467/
https://ncbi.nlm.nih.gov/pubmed/22479203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002608
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