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SAME PREVENTS THE INDUCTION OF THE IMMUNOPROTEASOME AND PRESERVES THE 26S PROTEASOME IN THE DDC-INDUCED MDB MOUSE MODEL
Mallory-Denk Bodies (MDBs) form in the liver of alcoholic patients. This occurs because of the accumulation and aggregation of ubiquitinated cytokeratins, which hypothetically is due to the ubiquitin-proteasome pathway’s (UPP) failure to degrade the cytokeratins. The experimental model of MDB format...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315394/ https://ncbi.nlm.nih.gov/pubmed/20223233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2010.03.001 |
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