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SAME PREVENTS THE INDUCTION OF THE IMMUNOPROTEASOME AND PRESERVES THE 26S PROTEASOME IN THE DDC-INDUCED MDB MOUSE MODEL

Mallory-Denk Bodies (MDBs) form in the liver of alcoholic patients. This occurs because of the accumulation and aggregation of ubiquitinated cytokeratins, which hypothetically is due to the ubiquitin-proteasome pathway’s (UPP) failure to degrade the cytokeratins. The experimental model of MDB format...

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Detalhes bibliográficos
Main Authors: Bardag-Gorce, Fawzia, Oliva, Joan, Li, Jun, French, Barbara A., French, Samuel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315394/
https://ncbi.nlm.nih.gov/pubmed/20223233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2010.03.001
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