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Structure and function of GDP-mannose-3′ ,5′ -epimerase; an enzyme which performs three chemical reactions at the same active site

GDP-mannose-3′,5′-epimerase (GME) from Arabidopsis thaliana catalyses the epimerization of both the 3′ and 5′ positions of GDP-α-d-mannose to yield GDP-β-l-galactose. Production of the C5′ epimer of GDP-α-d-mannose, GDP-β-l-gulose, has also been reported. The reaction occurs as part of vitamin C bio...

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Autori principali: Major, Louise L, Wolucka, Beata A, Naismith, James H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315049/
https://ncbi.nlm.nih.gov/pubmed/16366586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja056490i
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