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Effect of excess water on the desilylation of oligoribonucleotides using tetrabutylammonium fluoride.
The most commonly available 2' hydroxyl protecting group used in the synthesis of oligoribonucleotides is the tert-butyldimethylsilyl moiety. This protecting group is generally cleaved with 1 M tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF). The efficiency of this reaction was test...
Uloženo v:
| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1993
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC331499/ https://ncbi.nlm.nih.gov/pubmed/8233822 |
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