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Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers

Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition from one state to another at a tipping point. Here, we develop a model-free method to detect early-warning signals of such...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Luonan, Liu, Rui, Liu, Zhi-Ping, Li, Meiyi, Aihara, Kazuyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314989/
https://ncbi.nlm.nih.gov/pubmed/22461973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00342
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