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A Bayesian View on Cryo-EM Structure Determination

Three-dimensional (3D) structure determination by single-particle analysis of cryo-electron microscopy (cryo-EM) images requires many parameters to be determined from extremely noisy data. This makes the method prone to overfitting, that is, when structures describe noise rather than signal, in part...

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Bibliografiska uppgifter
Huvudupphovsman: Scheres, Sjors H.W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314964/
https://ncbi.nlm.nih.gov/pubmed/22100448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.11.010
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