Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

Actin-myosin interactions provide the driving force underlying each heartbeat. The current view is that actin-bound regulatory proteins play a dominant role in the activation of calcium-dependent cardiac muscle contraction. In contrast, the relevance and nature of regulation by myosin regulatory pro...

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Detalhes bibliográficos
Main Authors: Sheikh, Farah, Ouyang, Kunfu, Campbell, Stuart G., Lyon, Robert C., Chuang, Joyce, Fitzsimons, Dan, Tangney, Jared, Hidalgo, Carlos G., Chung, Charles S., Cheng, Hongqiang, Dalton, Nancy D., Gu, Yusu, Kasahara, Hideko, Ghassemian, Majid, Omens, Jeffrey H., Peterson, Kirk L., Granzier, Henk L., Moss, Richard L., McCulloch, Andrew D., Chen, Ju
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314469/
https://ncbi.nlm.nih.gov/pubmed/22426213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61134
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