Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis

Cilia are highly specialized microtubule-based organelles that have pivotal roles in numerous biological processes, including transducing sensory signals. Defects in cilia biogenesis and transport cause pleiotropic human ciliopathies. Mutations in over 30 different genes can lead to cilia defects, a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Rachel, Rivka A., May-Simera, Helen L., Veleri, Shobi, Gotoh, Norimoto, Choi, Byung Yoon, Murga-Zamalloa, Carlos, McIntyre, Jeremy C., Marek, Jonah, Lopez, Irma, Hackett, Alice N., Brooks, Matthew, den Hollander, Anneke I., Beales, Philip L., Li, Tiansen, Jacobson, Samuel G., Sood, Raman, Martens, Jeffrey R., Liu, Paul, Friedman, Thomas B., Khanna, Hemant, Koenekoop, Robert K., Kelley, Matthew W., Swaroop, Anand
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2012
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314468/
https://ncbi.nlm.nih.gov/pubmed/22446187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60981
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia